Immunomodulating compositions and methods of use thereof

Details Immunomodulating compositions and methods of use thereof Immunomodulating compositions and methods of use thereof

G - Physics

01

N

G01N 33/53 (2006.01) C07K 16/18 (2006.01) G01N 33/563 (2006.01)

Patent

CA 2760044

The invention is directed to ß 1-6 glucans, compositions, diagnostic kits, and devices comprising the same, and methods of use thereof in modulating immune response and treating, delaying progression of, reducing the incidence or severity of cancer, infection, inflammation, and autoimmune diseases. The ß 1-6 glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety. The ß 1-6 glucans of certain embodiments of the invention recruit immunoglobulin G antibodies to mediate complement and neutrophil killing. The conjugated ß 1-6 glucans of certain embodiments of the invention are targeted to cells to stimulate the immune response at the target location by activating complement-mediated lysis and recruitment of neutrophils.

Linvention porte sur des ß 1-6 glucanes, sur des compositions, sur des kits de diagnostic et sur des dispositifs les comportant, et sur leurs procédés dutilisation dans la modulation dune réponse immunitaire et le traitement, le retard de la progression, la réduction de lincidence ou de la gravité du cancer, dune infection, dune inflammation et de maladies auto-immunes. Les ß 1-6 glucanes de certains modes de réalisation de linvention sont enrichis en groupes O-acétylés et/ou conjugués à un support solide ou liés à une fraction de ciblage. Les ß 1-6 glucanes de certains modes de réalisation de linvention recrutent des anticorps dimmunoglobuline G pour une médiation par le complément et la mort des neutrophiles. Les ß 1-6 glucanes conjugués de certains modes de réalisation de linvention sont dirigés vers des cellules pour stimuler la réponse immunitaire au niveau dun emplacement de cible par lactivation dune lyse à médiation par le complément et dun recrutement de neutrophiles.

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