Immunomodulating compositions and uses therefor

Details Immunomodulating compositions and uses therefor Immunomodulating compositions and uses therefor

A - Human Necessities

61

K

A61K 35/12 (2006.01) C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61P 31/18 (2006.01) A61P 37/04 (2006.01) C40B 40/10 (2006.01)

Patent

CA 2711145

This invention discloses compositions that consist essentially of a Gag polypeptide or at least one portion thereof, and optionally antigen-presenting cells or their precursors, for treating or preventing lentiviral infections including the treatment or prevention of related acquired immunodeficiency diseases. In certain embodiments, the compositions consist essentially of a plurality of overlapping and/or non-overlapping peptides derived from a single Gag polypeptide or from different Gag polypeptides.

La présente invention concerne des compositions qui consistent essentiellement en un polypeptide Gag ou en au moins une partie de celui-ci, et éventuellement en des cellules présentant un antigène ou leurs précurseurs, en vue de traiter ou prévenir des infections lentivirales, y compris des maladies liées au syndrome de l'immunodéficience acquise. Dans certains modes de réalisation, lesdites compositions consistent essentiellement en une pluralité de peptides chevauchants et/ou non chevauchants, dérivés d'un seul polypeptide Gag ou de plusieurs polypeptides Gag différents.

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