A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 37/00 (2006.01) C07K 14/705 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2443050
The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling.
L'invention concerne la découverte du fait que la signalisation par l'intermédiaire d'un récepteur de sérotonine de type 1B, 2, 4 et 6 est importante dans l'activation des cellules T, de sorte que l'inhibition, telle que la signalisation peut être utilisée pour la modulation de la réponse immunitaire. L'immunomodulation est utile pour le traitement de maladies ou d'états immunologiques. Nous avons également découvert que, dans les cellules impliquées dans le processus de cycle cellulaire, l'inhibition de la signalisation de la sérotonine inhibe le processus et induit l'apoptose et des changements morphologiques d'une cellule. Ces effets d'inhibition de la signalisation sérotonergique peuvent être utiles pour la suppression des cellules et pour l'identification de composés qui inhibent la signalisation.
Albert Ross
Davidson Harold Carter
Jameson Bradford A.
Tretiakova Anna S.
Gowling Lafleur Henderson Llp
Philadelphia Health And Education Corporation
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