A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/505 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/5415 (2006.01) A61K 31/546 (2006.01) C07D 417/06 (2006.01) C07K 14/705 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2488708
The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling, such as by using fluphenazine, can be used to modulate the immune response, cell proliferation, and apoptosis, among other cell processes. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling. Additionally, methods for the use, identification and production of an inhibitor that does not substantially cross the blood-brain barrier are also provided.
L'invention concerne la découverte du fait que la signalisation par le biais d'un récepteur de sérotonine de type 1B, 2, 4 et 6 est importante dans l'activation des cellules T, de sorte que l'inhibition d'une telle signalisation, par exemple par utilisation de fluphénazine, peut servir à moduler notamment la réponse immunitaire, la prolifération cellulaire et l'apoptose. Cette immunomodulation est utile dans le traitement de maladies ou d'états immunologiques, et dans le développement de thérapeutiques éventuelles pour de tels maladies ou états. En outre, dans les cellules impliquées dans le processus de cycle cellulaire, l'inhibition de la signalisation de la sérotonine inhibe le processus et induit l'apoptose et des changements morphologiques d'une cellule. Cette action d'inhibition de la signalisation sérotonergique peut servir à tuer de manière sélective des cellules et à identifier des composés qui inhibent la signalisation. En outre, l'invention concerne des procédés d'utilisation, d'identification et de production d'un inhibiteur qui sensiblement ne traverse pas la barrière hémato-encéphalique.
Davidson Harold Carter
Jameson Bradford A.
Tretiakova Anna A.
Gowling Lafleur Henderson Llp
Philadelphia Health And Education Corporation (d/b/a Mcp Hahnema
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