A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/437 (2006.01)
Patent
CA 2724720
The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
La présente invention concerne des adjuvants immunitaires contenant des inhibiteurs dIAP, comprenant des mimétiques de Smac. Linvention concerne en outre des compositions pharmaceutiques et des vaccins contenant un inhibiteur dIAP et un antigène. La présente invention concerne en outre des procédés damélioration dune réponse immunitaire par administration dun inhibiteur dIAP, des procédés de traitement ou de prévention du cancer, des procédés de traitement ou de prévention des infections, des procédés de traitement de troubles auto-immuns, et des procédés de potentialisation de la production de cytokine ou danticorps.
Dougan Michael
Dranoff Glenn
Firestone Brant G.
Straub Christopher S.
Zawel Leigh
Dana-Farber Cancer Institute Inc.
Novartis Ag
Osler Hoskin & Harcourt Llp
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