Immunomodulation using altered dendritic cells

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 39/00 (2006.01) A61P 37/00 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2488774

The invention relates to altered immune cells and their use in methods and compositions to alter the immune system in a mammal. More specifically, the invention is directed to the alteration of gene expression in antigen presenting cells such as dendritic cells (DC) and their use in various methods and compositions to alter T cell activity for the treatment of a variety of immune disorders.

L'invention concerne des cellules immunitaires altérées et leur utilisation dans des méthodes et des compositions servant à altérer le système immunitaire d'un mammifère. L'invention concerne plus précisément l'altération de l'expression d'un gène dans des cellules présentant des antigènes, telles que des cellules dendritiques (CD), ainsi que leur utilisation dans diverses méthodes et compositions servant à altérer l'activité des lymphocytes T pour traiter divers troubles immunitaires.

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