Immunomodulation with novel pharmaceutical compositions

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 211/13 (2006.01) A61K 31/13 (2006.01)

Patent

CA 2526829

The present invention relates to the synthesis and use of a novel class of tumor necrosis factor inhibitors and immunomodulators. These compounds have pharmacological applications as well as uses in assays relating to tumor necrosis factor and other involved cytokines. As pharmaceuticals, these compounds are used to treat inflammatory, infectious, autoimmune or other proliferative diseases and conditions related to the unwanted presence or activity of tumor necrosis factor and/or one or more other involved cytokines, alone or in combination with other agents.

Cette invention se rapporte à la synthèse et à l'utilisation d'une nouvelle classe d'inhibiteurs et d'immunomodulateurs du facteur de nécrose tumorale. Ces composés se prêtent à des applications pharmacologiques et à des utilisations dans des dosages relatifs au facteur de nécrose tumorale et à d'autres cytokines impliquée. Comme agents pharmaceutiques, ces composés servent à traiter les maladies inflammatoires, infectieuses et auto-immunes ou d'autres maladie prolifératives, ainsi que les états relatifs à la présence ou à l'activité indésirée du facteur de nécrose tumorale et/ou d'une ou de plusieurs autres cytokines impliquées seuls ou en association avec d'autres agents.

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