Immunomodulators and antiviral agents

Details Immunomodulators and antiviral agents Immunomodulators and antiviral agents

C - Chemistry, Metallurgy

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C07D 473/00 (2006.01) C07D 239/48 (2006.01) C07D 473/30 (2006.01) C07D 473/34 (2006.01) C07D 473/38 (2006.01) C07D 473/40 (2006.01)

Patent

CA 1122217

ABSTRACT OF THE DISCLOSURE Compounds of the formula (Y)z Image where X is OH, NH2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R1 is H or alkyl of 1 to 8 carbon atoms, R2 is H or methyl, Y is the salt of an amine of the formula Image where R3 and R4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have antitumor activity. The compounds and compositions where z is 1 to 10 are novel per se. When R2 is H the presence of Y en- hances the immunoregulatory activity and the antiviral activity. If X is the NH2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.

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