C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 38/17 (2006.01)
Patent
CA 2638828
The invention relates to the development of peptides originating from sequence HYRIKPTFRRLKWKKYKGKFW, into which amino acid substitutions have been introduced, which guarantee the dissociation of the lipopolysaccharide-binding capacity and potentiate the anti-tumour and immunomodulatory effect. Said peptides and combinations thereof can be used in the treatment of cancer, as well as in synergism with other standard therapies.
L'invention porte sur le développement de peptides issus de la séquence HYRIKPTFRRLKWKKYKGKFW, et dans laquelle on a introduit des substitutions d'acides aminés, qui assurent la dissociation de la capacité de liaison au lipopolysaccharide, et qui potentialisent l'effet anti-tumoral et immunomodulateur. Lesdits peptides et leurs combinaisons peuvent être utilisés dans le traitement du cancer, ainsi qu'en synergie avec les thérapies classiques.
Acevedo Castro Boris Ernesto
Garay Perez Hilda Elisa
Guerra Vallespi Maribel
Guillen Nieto Gerardo Enrique
Madrazo Isis Del Carmen Torrens
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
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