Immunomodulatory compositions

Details Immunomodulatory compositions Immunomodulatory compositions

A - Human Necessities

61

K

A61K 31/407 (2006.01) A61K 31/7056 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01) C07H 17/02 (2006.01)

Patent

CA 2513881

Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula (I), wherein R is selected from the group comprising hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups, or a pharmaceutically acceptable salt or derivative thereof, are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, haemorestoration, alleviation of immunosuppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells.

La présente invention concerne des composés immunomodulateurs (p.ex. immunostimulants) isolés de pyrrolizidine polyhydroxylée de la formule (1), dans laquelle R est choisi dans le groupe composé de l'hydrogène, des groupes acyle, alkyle (p.ex. cycloalkyle), alcényle, alkynyle et aryle saturés ou insaturés, non substitués ou substitués, linéaires ou ramifiés, ou d'un sel ou d'un dérivé pharmaceutiquement acceptable de ces derniers, lesquels composés sont utilisés dans la thérapie et la prophylaxie, y compris pour augmenter la balance Th1 :Th2 de la réponse immunitaire, pour la restauration hématologique, pour soulager l'immunosuppression, pour stimuler les cytokines, pour traiter les troubles prolifératifs (p.ex. le cancer), pour la vaccination, pour stimuler la réponse immunitaire innée et pour renforcer l'activité des cellules NK endogènes.

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