Immunomodulatory compositions containing an...

A - Human Necessities – 61 – K

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A61K 39/39 (2006.01) A61K 39/35 (2006.01) A61K 39/36 (2006.01) A61K 39/385 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2391507

The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to antigen. The extent of conjugation affects immunomodulatory properties, such as extent of antigen-specific antibody formation, including Th1-associated antibody formation, and thus these various conjugate classes are useful for modulating the type and extent of immune response. The invention also includes methods of modulating an immune response using these compositions.

La présente invention concerne des classes de compositions immunomodulatrices comprenant en moyenne au moins une séquence immunostimulante contenant un polynucléotide conjugué ou attaché à un antigène. L'étendue de la conjugaison modifie les propriétés immunomodulatrices telles que l'étendue de la formation antigène-anticorps spécifique, y compris la formation d'anticorps associés au Th1, et ces différentes classes de conjugués sont par conséquent utilisées pour moduler le type et l'étendue de la réaction immunitaire. L'invention se rapporte également à des procédés permettant de moduler une réaction immunitaire à l'aide des compositions précitées..

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