A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 9/16 (2006.01) A61K 31/7088 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61P 37/02 (2006.01)
Patent
CA 2456328
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMO/MC) complexes comprising 3- 6mer immunomodulatory oligonucleotides. The IMO/MC complexes may be covalently or non-covalently bound. Also provided are immunomodulatory compositions comprising a 3-6m er IMO encapsulated in an MC.
L'invention concerne de nouvelles compositions et de nouveaux procédés pour l'immunomodulation des personnes. L'immunomodulation est réalisée par administration de complexes polynucléotides immunomodulateurs/microporteurs (IMO/MC) comprenant des oligonucléotides immunomodulateurs trimères à hexamères. Les complexes IMO/MC peuvent être liés par covalence ou non. L'invention se rapporte également à des compositions immunomodulatrices comprenant un oligonucléotide immunomodulateur trimère à hexamère encapsulé dans un microporteur.
Dina Dino
Fearon Karen L.
Borden Ladner Gervais Llp
Dynavax Technologies Corporation
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