Immunomodulatory compounds and treatment of diseases related...

Details Immunomodulatory compounds and treatment of diseases related... Immunomodulatory compounds and treatment of diseases related...

A - Human Necessities

61

K

A61K 31/661 (2006.01) A61K 31/198 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2645053

The invention relates to the use of immunomodulatory compounds for the treatment of diseases related to to an overproduction of inflammatory cytokines, such as diseases selected from the group consisting of asthma, atopic dermatitis, allergic rhinitis, prostatitis, inflammatory bowel disease, diabetes, and rhumatoid arthritis, said compounds being of general formula (I), wherein : m and n, independently from each other, are an integer ranging from 1 to 4, X and Y represent -COOH, -0-P(O)(OH)2, -O-SO2(OH), -NH2, -OH, -CONH(CH2)n1-NH2, -CO-NH-CH(COOH)-(CH2)n1COOH, -CO-NH-CH(COOH)- (CH2)n1-NH2, -O-CO-(CH2)n1-NH2,-O-CO-(CH2)n1-CHOH-CH2OH, -O-CO-(CH2)n1-OH, -O-CO-(CH2)n1-COOH, -O-CO-(CH2)n1-CHO, -O-CO-(CH2)n1-NH-CO-(CH2)n2-COOH, R1 and R2 each designate an acyl group derived from a saturated or unsaturated, straight-or branched-chain carboxylic acid having from 2 to 18 carbon atoms, which is unsubstituted or bears one to three substituents selected among hydroxyl, dihydroxyphosphoryloxy, alkyl of 2 to 18 carbon atoms, alkoxy of 2 to 18 carbon atoms, acyloxy of 2 to 18 carbon atoms in the acyl moiety, amino, acylamino.

L'invention concerne l'utilisation de composés immunomodulateurs pour le traitement de maladies associées à une surproduction de cytokines inflammatoires, telles que des maladies choisies dans le groupe constitué de l'asthme, la dermite atopique, la rhinite allergique, la prostatite, les maladies inflammatoires des intestins, le diabète et la polyarthrite rhumatoïde, lesdits composés ayant la formule générale (I) : Dans cette formule, m et n, indépendamment l'un de l'autre, sont un nombre entier situé dans la plage de 1 à 4, X et Y représentent un groupe -COOH, -O-P(O)(OH)2, -O-SO2(OH), -NH2, -OH, -CONH(CH2)n1-NH2, -CO-NH-CH(COOH)-(CH2)n1COOH, -CO-NH-CH(COOH)- (CH2)n1-NH2, -O-CO-(CH2)n1-NH2,-O-CO-(CH2)n1-CHOH-CH2OH, -O-CO-(CH2)n1-OH, -O-CO-(CH2)n1-COOH, -O-CO-(CH2)n1-CHO ou -O-CO-(CH2)n1-NH-CO-(CH2)n2-COOH, R1 et R2 désignent chacun un groupe acyle dérivé d'un acide carboxylique saturé ou insaturé à chaîne linéaire ou ramifiée ayant de 2 à 18 atomes de carbone, lequel n'est pas substitué ou porte d'un à trois substituants choisis parmi un groupe hydroxyle, un groupe dihydroxyphosphoryloxy, un groupe alkyle de 2 à 18 atomes de carbone, un groupe alcoxy de 2 à 18 atomes de carbone, un groupe acyloxy de 2 à 18 atomes de carbone dans le groupement acyle, un groupe amino, un groupe acylamino.

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