Immunomodulatory formulations and methods for use thereof

Details Immunomodulatory formulations and methods for use thereof Immunomodulatory formulations and methods for use thereof

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/16 (2006.01) A61K 39/39 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2402294

The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a nonbiodegradable microcarrier or nanocarrier.

L'invention concerne de nouvelles compositions et des procédés destinés à l'immunomodulation de sujets. L'immunomodulation est obtenue par l'administration de complexes polynucléotide immunomodulateur/microsupport. Ces complexes peuvent être liés de manière covalente ou non covalente, et contiennent un polynucléotide incluant au moins une séquence immunostimulatrice liée à un microsupport ou à un nanosupport non biodégradable.

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