A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7088 (2006.01) A61K 31/7084 (2006.01) A61P 37/06 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2560114
Oligonucleotides containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unmethylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use in antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
Klinman Dennis
Krieg Arthur M.
Steinberg Alfred D.
Coley Pharmaceutical Group Inc.
Cpg Immunopharmaceuticals Inc.
Departmen T. Of Health And Human Services The United States Of America As Represented By The Secretary
Department Of Health & Human Services (the) United States Of America As Represented By The Secretary
Smart & Biggar
LandOfFree
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