Immunomodulatory properties of multipotent adult progenitor...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 35/28 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2628254

Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.

L~invention décrit des cellules isolées qui ne sont ni des cellules souches embryonnaires, ni des cellules germes embryonnaires, ni des cellules germes. Les cellules peuvent être réparties en au moins un type de cellule de chacun d~au moins deux éléments parmi les lignages endodermiques, ectodermiques et mésodermiques. Les cellules ne provoquent pas de réponse immunitaire nocive. Les cellules peuvent moduler les réponses immunitaires. A titre d~exemple, les cellules peuvent supprimer une réponse immunitaire chez un hôte engendré par des cellules, des tissus et des organes allogènes. L~invention décrit des procédés d~utilisation des cellules, seules ou bien de manière adjonctive, pour traiter des sujets. Par exemple, les cellules peuvent s~utiliser de manière adjonctive pour une immunosuppression dans la thérapie par transplantation. L~invention décrit également des procédés d~obtention des cellules et des compositions permettant de les utiliser.

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