A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61P 37/02 (2006.01)
Patent
CA 2759332
Disclosed are synthetic nanocarrier compositions, and related methods, for treating diseases in which generating a Th1 -biased immune response is desirable. In an aspect, the invention relates to a composition for treatment of a condition com-prising: synthetic nanocarriers comprising (1) an immunofeature surface, an (2) a Th1 biasing immunostimulatory agent coupled to the synthetic nanocamers; and a pharmaceutically acceptable excipient; wherein the immunofeature surface does not comprise antigen that is relevant to treatment of the condition in an amount sufficient to provoke an adaptive immune response to the anti-gen that is relevant to treatment of the condition. In another aspect, the invention relates to a method comprising: identifying a subject suffering from a condition; providing a composition that comprises synthetic nanocarriers that comprise (1) an APC tar-geting feature, and (2) a Th1 biasing immunostimulatory agent coupled to the synthetic nanocarriers; and a pharmaceutically ac-ceptable excipient; and administering the composition to the subject; wherein the administration of the composition does not fur-ther comprise co-administration of an antigen that is relevant to treatment of the condition. In yet another aspect, the invention re-lates to a method comprising: providing a composition comprising synthetic nanocarriers that comprise a Th1 biasing immunos-timulatory agent and an APC targeting feature; administering the composition to a subject; and administering an antigen to the subject to which a Th1 biased response is desired at a time different from administration of the composition to the subject; where-in administration of the antigen comprises passive administration or active administration.
L'invention porte sur des compositions de nanosupport synthétiques et sur des procédés associés pour traiter des maladies dans lesquelles il est désirable de générer une réponse immunitaire à médiation par Th1.
Bratzler Robert L.
Lipford Grayson B.
Selecta Biosciences Inc.
Smart & Biggar
LandOfFree
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