Immunoneutral silk-fiber-based medical devices

Details Immunoneutral silk-fiber-based medical devices Immunoneutral silk-fiber-based medical devices

D - Textiles, Paper

02

G

D02G 3/02 (2006.01) A61L 15/32 (2006.01) A61L 17/00 (2006.01) D03D 15/00 (2006.01) D04B 1/14 (2006.01) D06L 1/12 (2006.01)

Patent

CA 2518509

Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.

Dans cette invention, on purifie de la soie pour en éliminer les composants immunogènes (notamment la séricine) et on utilise la soie ainsi purifiée pour former des tissus qui servent à constituer des prothèses de support tissulaire pour implantations. Ces tissus peuvent porter des groupes fonctionnels, des médicaments et d'autres réactifs biologiques. Les applications de ces prothèses sont notamment la réparation des hernies, la reconstruction des parois tissulaires et le soutien d'organes, par exemple sous la forme de bandelettes de soutien de la vessie. Ces fibres de soie sont disposées en parallèle et, éventuellement, entrelacées (par exemple torsadées) pour former une structure; la séricine pouvant être extraite à n'importe quel moment pendant la formation du tissu, laissant ainsi une structure de fibres de fibroïne de soie ayant une excellente résistance à la traction et d'autres propriétés mécaniques.

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