Immunopotentiating inosine monophosphate 5'-nucleotidase...

Details Immunopotentiating inosine monophosphate 5'-nucleotidase... Immunopotentiating inosine monophosphate 5'-nucleotidase...

C - Chemistry, Metallurgy

07

H

C07H 19/20 (2006.01) A61K 31/70 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 39/29 (2006.01) A61K 39/39 (2006.01) A61P 37/02 (2006.01) C07H 19/10 (2006.01) C07K 5/068 (2006.01) C07K 5/09 (2006.01) C07K 5/11 (2006.01)

Patent

CA 2218701

A method of making inosine-5'-monophosphate and its derivatives resistant to 5'-nucleotidase by chem-ically modifying inosine-5'-monophosphate to formula (I) wherein R is selected from the group consisting of an alkyl, alkoxy and secondary amino compounds whereby inosine-5'-monophosphate biological activity is retained in vivo.

L'invention concerne un procédé pour préparer l'inosine-5'-monophosphate et des dérivés de ce composé résistants à la 5'-nucléotidase. Ces dérivés ont la formule (I). Dans cette formule, R est choisi parmi les groupes alkyle, alcoxy et amine secondaire et ces dérivés conservent in vivo l'activité de l'inosine-5'-monophosphate.

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