Immunoreactive peptide ctl epitopes of human cytomegalovirus...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/38 (2006.01) A61K 39/245 (2006.01) A61K 39/25 (2006.01) C07K 14/045 (2006.01) C12N 7/01 (2006.01) C12N 15/66 (2006.01)

Patent

CA 2425202

The invention provides peptides which are immunogenic epitopes recognized by CD8+ class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent cytomegalovirus (HCMV) infection. The peptides are capable of activating CTL in the absence of active viral replication, and thus are useful for eliciting a cellular immune response against HCMV by normal and immunodeficient subjects. Vaccines against HCMV, with and without adjuvants, and immunological and diagnostic reagents are disclosed.

L'invention concerne des peptides qui sont des épitopes immunogéniques reconnus par des lymphocytes T cytotoxiques CD8 + de classe I à restriction au CMH chez les patients couvant une infection latente par le cytomégalovirus (HCMV). Ces peptides, qui sont capables d'activer les CTL en l'absence de réplication virale active, conviennent pour éliciter une réponse immunitaire cellulaire contre le HCMV de la part de sujets normaux et de sujets immunodéficients. L'invention concerne également des vaccins contre le HCMV, avec ou sans adjuvants, ainsi que des réactifs immunologiques et de diagnostic.

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