G - Physics – 01 – N
Patent
G - Physics
01
N
167/41, 167/43
G01N 33/547 (2006.01) G01N 33/543 (2006.01)
Patent
CA 1291030
IMMUNOREACTIVE REAGENT, METHOD OF PREPARATION AND ITS USE TO DETERMINE AN IMMUNOREACTIVE SPECIES Abstract of the Disclosure A reagent useful in the determination of an immunoreactive species comprises water-insoluble particles having tracer molecules associated there with. Bound to the outer surface of the particles are; (i) receptor molecules which are reactive with the species, and (ii) molecules of a protein having pI less than about 6, and which protein is not reac- tive with either the species or the receptor mole- cules. The weight ratio of the receptor molecules to the low pI protein molecules is from about 100:1 to about 1:10. This reagent is useful in agglutination and other immunological reactions. A method of pre- paring the reagent includes providing a suspension of the particles and contacting them with the receptor molecules and low pI protein so as to attach both to the particles. The protein is present in the suspen- sion in an amount such that substantially all of it is attached to the particles. The reagent thus pre- pared can be used, for example, in agglutination assays for the determination of a multivalent immuno- reactive species, such as Streptococcus A antigen.
553845
Snyder Brian A.
Warren Harold C. III
Eastman Kodak Company
Gowling Lafleur Henderson Llp
Snyder Brian A.
Warren Harold C. III
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