A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/08 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 9/06 (2006.01) G01N 33/531 (2006.01) G01N 33/532 (2006.01) G01N 33/535 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2151614
This invention describes a non-radioactive targeting immunoreagent comprised of the residue of a proteinaceous active site of a dihydrofolate reductase enzyme (DHFR), a linking group, and the residue of an immunoreactive material together with a radioactive delivery agent comprised of the residue of a ligand which has an affinity for non-covalent binding to said DHFR receptor moiety, a linking group, and the residue of a radioactive agent. This invention also describes a non-radioactive targeting immunoreagent comprised of the residue of a ligand which has an affinity for non-covalent binding to a DHFR proteinaceous active site receptor moiety, a linking group, and the residue of an immunoreactive material together with a radioactive delivery agent comprised of the residue of a DHFR proteinaceous active site receptor moiety, a linking group, and a radioactive agent. These compositions comprise useful systems for the production of an amplification of delivery of the radioactive agent to tumor sites in the therapy and diagnostic imaging of cancer.
Black Christopher Douglas Valiant
Kruse Lawrence I.
Shearman Clyde William
Snow Robert Allen
Swabey Ogilvy Renault
The Wellcome Foundation Limited
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