C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2154896
In one aspect, this invention describes a non-radioactive targeting immunoreagent comprised of the residue of a proteinaceous half of a heterodimeric molecule (H1), a linking group, and the residue of an immunoreactive material together with a radioactive delivery agent comprised of a proteinaceous second half of a heterodimeric molecule (H2), a linking group, and a radioactive agent. In another aspect, this invention describes a non-radioactive targeting immunoreagent comprised of the residue of a proteinaceous half of a heterodimeric molecule (H2), a linking group, and the residue of an immunoreactive material together with a radioactive delivery agent comprised of the residue of a proteinaceous second half of a heterodimeric molecule (H1), a linking group, and a radioactive agent. These compositions comprise useful systems for the production of an amplification of delivery of the radioactive agent to tumor sites in the therapy and diagnostic imaging of cancer.
Black Christopher Douglas Valiant
Shearman Clyde William
Snow Robert Allen
Swabey Ogilvy Renault
The Wellcome Foundation Limited
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