C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/21 (2006.01) C07K 14/73 (2006.01) C07K 16/10 (2006.01) C07K 16/46 (2006.01) C12N 5/12 (2006.01) G01N 33/532 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2043418
Immunoreagents Reactive With a Conserved Epitope of Human Immunodeficiency Virus Type I (HIV-1) gp120 and Methods of Use Abstract The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV- 1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, prevention, amelioration and treatment of HIV disease, primarily AIDS (Acguired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV- 1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease.
Ho David Da-I
Robinson James Edmund
Cedars-Sinai Medical Center
Louisiana State University And Agricultural And Mechanical Colle
Smart & Biggar
LandOfFree
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