Immunoregulatory antibodies and uses thereof

Details Immunoregulatory antibodies and uses thereof Immunoregulatory antibodies and uses thereof

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2436180

A combination antibody therapy for treating B cell malignancies using an immunoregulatory antibody, especially an anti-B7, anti-CD23, or anti-CD40L antibody and a B cell depleting antibody, especially anti-CD19, anti-CD20, anti-CD22 or anti-CD37 antibody is provided. Preferably, the combination therapy will comprise anti-B7 and anti-CD20 antibody administration.

L'invention porte sur une polythérapie aux anticorps destinée à traiter des cellules B malignes au moyen d'un anticorps immunorégulateur, en particulier un anticorps anti-B7, anti-CD23, ou anti-CD40L; et d'un anticorps de déplétion des cellules B, en particulier un anticorps anti-CD19, anti-CD20, anti-CD22 ou anti-CD37. De préférence, cette polythérapie consiste à administrer un anticorps anti-B7 et anti-CD20.

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