Immunoregulatory compositions

Details Immunoregulatory compositions Immunoregulatory compositions

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/06 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2386815

Genes which are differentially expressed in certain T cell populations are described together with their expression products (e.g. cognate proteins), cognate receptors, regulators, binding partners, and inhibitors or mimetics thereof. In particular, pharmaceutical compositions are described for treatment of an inflammatory or immune disorder and therapeutic and prophylactic methods based on their use, as targets for therapeutic intervention, of components of the Treg immunoregulatory pathway.

L'invention concerne des gènes exprimés de manière différentielle dans certaines populations de lymphocytes T ainsi que leurs produits d'expression (protéines parentes, par exemple), récepteurs parents, régulateurs, partenaires de liaison et inhibiteurs ou leurs mimétiques. Plus particulièrement, l'invention concerne des compositions pharmaceutiques destinées au traitement d'un trouble inflammatoire ou immunitaire, ainsi que des méthodes thérapeutiques et prophylactiques basées sur l'utilisation de composants de la voie immunorégulatrice Treg comme cibles destinées à une intervention thérapeutique.

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