A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/606 (2006.01) A61K 31/196 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2495537
Compounds are disclosed having the structure of Formula (I), where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is (II), where R5 is selected from the group consisting of hydrogen and C1 to C4 alkyl, or (III), where R6, R7 in R8 are independently hydrogen or C1 to C4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed (IV), where R9, R10 and R11 are independently selected from the group consisting of hydrogen and C1 to C4 alkyl, and R12 is selected from the group consisting of hydrogen and -C(O)R13, where R13 is a C1 to C6 alkyl or an aryl group.
L'invention concerne des composés ayant la structure de la formule (I), dans laquelle R1, R3 et R4 sont indépendamment de l'hydrogène ou de l'alkyle C1 à C4, et R2 est (II), où R5 est choisi parm le groupe composé d'hydrogène et de l'alkyle C1 à C4, ou (III), où R6, R7 dans R8 sont indépendamment de l'hydrogène ou de l'alkyle C1 à C4; ou des esthers ou des sels pharmacologiquement acceptables de ces composés. On peut utiliser ces composés pour la prophylaxie ou le traitement de diverses maladies, particulièrement des conditions inflammatoires de la voie gastro-intestinale. L'invention vise également des méthodes de traitement des conditions inflammatoires de la voie gastro-intestinale, comme la maladie intestinale inflammatoire, au moyen de composés ayant la formule (IV), dans laquelle R9, R10 et R11 sont indépendamment choisis parmi le groupe composé d'hydrogène et d'alkyle C1 à C4, et R12 est choisi parmi le groupe composé d'hydrogène et de -C(O)R13, où R13 est un alkyle C1 à C6 ou un groupe arylique.
Ekwuribe Nnochiri N.
Riggs-Sauthier Jennifer
Biocon Limited
Nobex Corporation
Sim & Mcburney
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