Immunoregulatory compounds, derivatives thereof and their use

Details Immunoregulatory compounds, derivatives thereof and their use Immunoregulatory compounds, derivatives thereof and their use

C - Chemistry, Metallurgy

07

C

C07C 245/08 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 31/215 (2006.01) A61K 31/655 (2006.01)

Patent

CA 2420576

Compounds are disclosed having the structure of Formula (I), where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is (II), where R5 is selected from the group consisting of hydrogen and C1 to C4 alkyl, or (III), where R6, R7 and R8 are independently hydrogen or C1 to C4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed (IV), where R9, R10 and R11 are independently selected from the group consisting of hydrogen and C1 to C4 alkyl, and R12 is selected from the group consisting of hydrogen and -C(O)R13, where R13 is a C1 to C6 alkyl or an aryl group.

Cette invention concerne des composés, ou bien des esters ou bien des sels pharmaceutiquement acceptables de ces composés, dont la structure est représentée par la formule (I). Dans cette formule, R?1¿, R?3¿, et R?4¿ sont indépendamment hydrogène ou alkyle en C¿1?-C¿4?, et R?2¿ est représenté par la formule (II), dans laquelle R?5¿ est pris dans le groupe comprenant hydrogène et alkyle en C¿1?-C¿4?, ou bien (III), dans laquelle R?6¿, R?7¿ et R?8¿ sont indépendamment hydrogène ou alkyle en C¿1?-C¿4?. De tels composés peuvent être utilisés pour la prophylaxie ou le traitement de diverses pathologies, en particulier des maladies inflammatoires de l'appareil gastro-intestinal. L'invention concerne également des méthodes de traitement de troubles inflammatoires de l'appareil gastro-intestinal tels que la maladie intestinale inflammatoire au moyen de composés représentés par la formule (IV). Dans cette formule, R?9¿, R?10¿ et R?11¿ sont pris indépendamment dans le groupe composé d'hydrogène et d'alkyle en C¿1?-C¿4?, et R?12¿ est pris dans le groupe composé d'hydrogène et de -C(O)R?13¿, où R?13¿ est un alkyle en C¿1?-C¿6? ou un groupe aryle.

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