A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 31/075 (2006.01) A61K 31/215 (2006.01) A61K 31/70 (2006.01) A61K 31/7008 (2006.01) A61K 31/7016 (2006.01) A61K 39/00 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) A61P 37/02 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2477191
The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising at least one aminoalkyl glucosaminide phosphate compound and at least one saponin compound. Such compositions synergistically enhance the immune response in a mammal to a co- administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.
L'invention concerne des compositions pharmaceutiques, en particulier des compositions de vaccins, qui renferment un systme adjuvant contenant au moins un compos~ de phosphate d'aminoalkyl glucosaminide et au moins un compos~ de saponine. Ces compositions favorisent de fa×on synerg~tique la r~ponse immunitaire d'un mammifre ~ un antigne administr~ conjointement. Par ailleurs, l'invention concerne des proc~d~s d'utilisation de ces compositions dans le traitement de diverses maladies humaines, y compris le cancer, ainsi que des infections microbiennes et des maladies auto-immunes.
Baldridge Jory R.
Evans Jay T.
Evans Lawrence
Mossman Sally
Antigenics Inc.
Battison Williams Dupuis
Corixa Corporation
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