Immunostimulating agents

Details Immunostimulating agents Immunostimulating agents

A - Human Necessities

61

K

A61K 31/7125 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 37/04 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2527756

An immunostimulant of a novel type which is a complex of an immunostimulant oligonucleotide with a carrier having a high safety and a high transfection effect. A complex comprising an immunostimulant oligonucleotide and a polysaccharide having a .beta.-1,3-bond (preferably a .beta.-1,3-glucan such as schizophyllan) is formed and then administered as an immunostimulant. Preferable examples of the immunostimulant oligonucleotide include a nonmethylated CpG motif. As the polysaccharide, it is favorable to use one modified with a nucleic acid-binding and/or cytophilic functional group.

L'invention concerne un immunostimulant d'un nouveau type, à savoir un complexe d'un oligonucléotide immunostimulant avec un transporteur très sûr et à effet de transfection élevé. L'invention concerne également la formation d'un complexe comprenant un oligonucléotide immunostimulant et un polysaccharide à liaison .beta.-1,3 (de préférence, un glucane .beta.-1,3 tel que le schizophyllane), qui est ensuite administré comme immunostimulant. Les exemples préférés de l'oligonucléotide immunostimulant comprennent un motif CpG non méthylé. En ce qui concerne le polysaccharide, il est préférable d'utiliser un polysaccharide modifié à l'aide d'un groupe fonctionnel de liaison aux acides nucléiques et/ou cytophile.

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