A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/145 (2006.01) A61K 9/127 (2006.01) A61K 39/29 (2006.01) A61K 39/39 (2006.01) C12N 7/00 (2006.01)
Patent
CA 2086831
Disclosed are immunostimulating reconstituted influenza virosomes (IRIVs) comprising the following components: (a) a mixture of phospholipids; (b) essentially reconstituted functional virus envelopes; (c) an influenza hemagglutinin protein (HA) or a derivative thereof which is biologically active and capable of inducing the fusion of said IRIV with cellular membranes and of inducing the lysis of said IRIV after endocytosis by antigen presenting cells, preferably macrophages or B cells; and (d) an antigen, and vaccines containing these IRIVs.
Virosomes de la grippe reconstitués immunostimulants (IRIV) renfermant les composants suivants: (a) un mélange de phospholipides; (b) des enveloppes virales fonctionnelles principalement reconstituées; (c) une protéïne hémagglutinine de la grippe (HA) ou un dérivé de celle-ci qui soit biologiquement actif et capable d'induire la fusion desdits IRIV avec des membranes cellulaires et d'induire la lyse desdits IRIV après endocytose par des cellules présentant un antigène, de préférence des macrophages ou des cellules B; et (d) un antigène, et des vaccins contenant ces IRIV.
Gluck Reinhard
Mischler Robert
Blake Cassels & Graydon Llp
Crucell Switzerland Ag
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