Immunostimulating guanine derivatives, compositions and methods

Details Immunostimulating guanine derivatives, compositions and methods Immunostimulating guanine derivatives, compositions and methods

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/167 (2006.01) A61K 31/70 (2006.01) A61K 39/39 (2006.01) C07H 19/16 (2006.01)

Patent

CA 1320196

Abstract 7,8-Disubstituted guanosine nucleoside derivatives are found to be potent immune response enhancing agents in human and animal cells. 7-Substituents are heteroatom-substituted-hydrocarbyl radicals having a length greater than ethyl and less than about decyl. 8-Substituents are =0, =S, =Se and =NCN. Compositions and methods of use are also disclosed.

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