Immunostimulatory, covalently lipidated oligonucleotides

Details Immunostimulatory, covalently lipidated oligonucleotides Immunostimulatory, covalently lipidated oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2474709

Covalently lipidated oligonucleotides comprising the CpG dinucleotide unit, or an analogue thereof, may be used as immunostimulatory agents to protect against a disease caused by a cancer cell or a pathogen, either alone or in conjunction with immunogens and/or non-immunological agents. Lipidated oligonucleotides with special backbones, lipidated oligonucleotides with fewer than eight nucleotides, and lipidated oligonucleotides comprising a plurality of CpG dinucleotide-containing segments connected by a long internucleoside linkage are of particular interest. These compounds are also novel per se.

L'invention concerne des lipido-oligonucléotides covalents comprenant une unité dinucléotide CpG, ou un analogue de celle-ci, pouvant être utilisé en tant qu'agents immunostimulants pour se protéger contre une maladie entraînée par des cellules cancéreuses ou un pathogène, soit seul, soit associé à des immunogènes et/ou des agents non immunologiques. Les lipido-oligonucléotides à squelette spécial, des lipido-oligonucléotides à moins de huit nucléotides, et les lipido-oligonucléotides comprenant plusieurs segments contenant des dinucléotides CpG reliés par une liaison longue internucléosidique sont d'intérêt particulier. Ces composés sont également nouveaux <i>per se</i>.

Affiliated with

Also associated with

Rating

Immunostimulatory, covalently lipidated oligonucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunostimulatory, covalently lipidated oligonucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunostimulatory, covalently lipidated oligonucleotides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1510018