C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/00 (2006.01) A61K 31/175 (2006.01) A61K 31/335 (2006.01) A61K 31/47 (2006.01) A61K 31/4706 (2006.01) A61K 31/70 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2270345
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as synthetic adjuvant.
L'invention concerne des séquences d'acide nucléique contenant des dinucléotides CpG non méthylés qui modulent une réponse immunitaire. La méthode consiste à stimuler une séquence Th1 d'activation immunitaire, la production de cytokine, l'activité lytique des cellules NK, et la prolifération des cellules B. Ces séquences sont également utiles comme adjuvant de synthèse.
Kline Joel N.
Klinman Dennis
Krieg Arthur M.
Steinberg Alfred D.
Weiner George
Coley Pharmaceutical Group Inc.
Department Of Health & Human Services (the) United States Of America As Represented By The Secretary
Smart & Biggar
The University Of Iowa Research Foundation
University Of Iowa Research Foundation
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