Immunostimulatory nucleic acids

Details Immunostimulatory nucleic acids Immunostimulatory nucleic acids

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A23L 1/30 (2006.01) A61K 31/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2388055

The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25 % T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/or greater than 50 % c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.

L'invention concerne des compositions d'acides nucléiques immunostimulateurs et des méthodes d'utilisation des compositions. Les acides nucléiques riches en T (thymidine) contiennent des séquences poly T et/ou présentent plus de 25 % de restes de nucléotides T. Les acides nucléiques TG présentent des dinucléotides TG. Les acides nucléiques riches en C présentent au moins une région poly-C et/ou plus de 50 % de nucléotides C. Ces acides nucléiques immunostimulateurs fonctionnent d'une manière similaire à celle des acides nucléiques contenant des motifs CpG. L'invention concerne également des acides nucléiques CpG préférés.

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