Immunostimulatory nucleic acids for inducing il-10 responses

Details Immunostimulatory nucleic acids for inducing il-10 responses Immunostimulatory nucleic acids for inducing il-10 responses

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2560108

The invention relates to methods and products for inducing IL-10 expression using immunostimulatory nucleic acids. In particular, the invention relates to methods and products for inducing IL-10 expression without inducing high levels of IFN-.alpha. expression. IL-10-inducing immunostimulatory nucleic acids preferably include a TC dinucleotide at the 5' end and a CG dinucleotide towards the 3' end, but not near the 5' end. The invention is useful for treating and preventing disorders associated with a Thl or Th2 immune response or for promoting a T regulatory cell environment suitable for suppressing inappropriate immune responses (e.g., for controlling or suppressing excessive immune responses).

L'invention concerne des procédés et des produits pour induire l'expression d'IL-10 en utilisant des acides nucléiques immunostimulateurs. Elle concerne notamment des procédés et des produits pour induire l'expression d'IL-10 sans provoquer des niveaux élevés de l'expression d'IFN-?. Des acides nucléiques immunostimulateurs d'IL-10 comprennent de préférence un dinucléotide TC à l'extrémité 5' et un dinucléotide CG vers l'extrémité 3' mais pas près de l'extrémité 5'. L'invention est utile dans le traitement et la prévention de troubles associés à la réaction immunitaire ThI ou Th2, ou pour la promotion d'un environnement de lymphocytes T régulateurs, conçu pour supprimer les réactions immunitaires non appropriées (p. ex., pour contrôler ou supprimer des réactions immunitaires excessives).

Affiliated with

Also associated with

Rating

Immunostimulatory nucleic acids for inducing il-10 responses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunostimulatory nucleic acids for inducing il-10 responses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunostimulatory nucleic acids for inducing il-10 responses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1742524