C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 39/39 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2487904
Oligonucleotides containing the non-palindromic sequence motif X1X2X3X4X5X6X7X8, wherein X1 is C or T, X2 is C, T, G or A, X3 is T or A, X4 is T, C or G, X5 is T, C or G, X6 is T or G, X7 is G and X8 is T and wherein at least two of X3, X4, X5 and X6 are Ts and wherein C never precedes G (in other terms, the nucleic acid motif does not consist of a CpG oligonucleotides) that have the ability to stimulate the immune response of animals of the order Primate, including humans are disclosed. The stimulation of the immune response is characterized by stimulation of proliferation, differentiation, cytokine production and antibody production in B-cells and cell differentiation and cytokine production in plasmacytoid dendritic cells.
Oligonucléotides contenant le motif de séquence non palindromique X¿1?X¿2?X¿3?X¿4?X¿5?X¿6?X¿7?X¿8?, dans lequel X¿1? est C ou T, X¿2? est C, T, G ou A, X¿3? est T ou A, X¿4? est T, C ou G, X¿5? est T, C ou G, X¿6? est T ou G, X¿7? est G et X¿8? est T, et dans lesquels au moins deux parmi X¿3?, X¿4?, X¿5? et X¿6? sont Ts, à condition que C ne précède jamais G (en d'autres termes, le motif d'acide nucléique n'est pas constitué d'oligonucléotides CpG) qui ont la capacité de stimuler la réponse immunitaire des animaux de l'ordre <i>Primate</i>, y compris les humains. La stimulation de la réponse immunitaire est caractérisée par la stimulation de la prolifération, de la différentiation, et de la production de cytokines ainsi que de la production d'anticorps dans les cellules B et la différentiation de cellules et la production de cytokines dans des cellules dendritiques plasmacytoïdes.
Bull Housser & Tupper Llp
Immunotech S.a.
LandOfFree
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