C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 31/715 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) C07K 2/00 (2006.01) C07K 14/52 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2330225
Immunomodulatory oligonucleotide compositions are disclosed. These oligonucleotides comprise an immunostimulatory hexanucleotide sequence comprising a modified cytosine. These oligonucleotides can be administered in conjunction with an immunomodulatory peptide or antigen. Methods of modulating an immune response upon administration of the oligonucleotide comprising a modified immunostimulatory sequence are also disclosed.
La présente invention concerne des compositions oligonucléotidiques immunostimulatrices, Ces olignucléotides comprennent une séquence d'hexanucléotides immunostimulateurs renfermant une cytosine modifiée. Ces oligonucléotides peuvent être administrés conjointement avec un peptide ou un antigène immunostimulateur. L'invention s'applique également à des méthodes qui permettent de moduler une réponse immunitaire par administration d'un oligonucléotide renfermant une séquence immunostimulatrice modifiée.
Borden Ladner Gervais Llp
Dynavax Technologies Corporation
LandOfFree
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