Immunostimulatory oligoribonucleotides

Details Immunostimulatory oligoribonucleotides Immunostimulatory oligoribonucleotides

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 9/127 (2006.01) A61K 31/7105 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2630738

The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence- dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immnostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).

L'invention concerne des compositions immunostimulatrices et l'utilisation de ces composés dans la préparation de médicaments utilisés dans le traitement de maladies ainsi que dans des utilisations in vitro. Les compositions de l'invention comprennent, en particulier, des oligoribonucléotides immunostimulateurs incorporant un motif séquentiel immunostimulateur dépendant de la séquence. L'invention concerne également des modifications spécifiques associées à des liaisons phosphate, des analogues des nucléotides, des composés d'addition et des combinaisons de ceux-ci. Les compositions de l'invention, pouvant éventuellement contenir un antigène, peuvent être utilisées seules ou conjointement à d'autres traitements pour stimuler ou améliorer une réponse immune. L'invention concerne également des compositions et des méthodes utilisées dans le traitement d'un sujet souffrant d'une infection, d'un cancer, d'une allergie, d'asthme, d'un remodelage des voies aériennes, ou d'une immunodéficience. Les oligoribonucléotides immunostimulateurs de l'invention stimuleraient le récepteur 8 de type Toll (TLR8).

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