A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 39/36 (2006.01) A61K 39/39 (2006.01)
Patent
CA 2268825
Immunostimulatory polynucleotide-immunomodulatory molecule conjugate compositions are disclosed. These compositions include a polynucleotide that is linked to an immunomodulatory molecule, which molecule comprises an antigen and may further comprise immunomodulators such as cytokines and adjuvants. The polynucleotide portion of the conjugate includes at least one immunostimulatory oligonucleotide nucleotide sequence (ISS). Methods of modulating an immune response upon administration of the polynucleotide-immunomodulatory conjugate preparation to a vertebrate host are also disclosed.
Compositions à base de conjugués d'un polynucléotide immunostimulateur et d'une molécule immunomodulatrice, qui comportent un polynucléotide lié à une molécule immunomodulatrice. Ladite molécule comporte un antigène et peut en outre comporter des immunomodulateurs tels que des cytokines et des adjuvants. La partie polynucléotide du conjugué comprend au moins une séquence nucléotidique constituée d'oligonucléotides immunostimulateurs (ISS). Des méthodes de modulation de la réponse immunitaire après administration de la préparation contenant le conjugué polynucléotide/immunomodulateur à un hôte vertébré sont également décrites.
Carson Dennis A.
Raz Eyal
Roman Mark
Mbm Intellectual Property Law Llp
The Regents Of The University Of California
LandOfFree
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