Immunostimulatory properties of oligonucleotide-based...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 39/00 (2006.01) C12N 15/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2628306

The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunostimulatory oligonucleotides according to the invention further comprise at least two oligonucleotides linked at their 3' ends, intemucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5' end.

L'invention concerne l'utilisation thérapeutique d'oligonucléotides en tant qu'agents immunostimulateurs dans des applications en immunothérapie. Plus spécifiquement, l'invention concerne un oligonucléotide immunostimulateur destiné à être utilisé dans des procédés de production d'une réponse immunitaire ou des méthodes de traitement d'un patient ayant besoin d'immunostimulation. Les oligonucléotides immunostimulateurs de cette invention comprennent de préférence de nouvelles purines. Ces oligonucléotides immunostimulateurs comprennent également au moins deux oligonucléotides liés au niveau de leurs terminaisons 3', de leurs liaisons internucléosidiques, de leur nucléobase fonctionnalisée ou de leur sucre à une séquence de liaison non nucléotidique, au moins un des oligonucléotides étant un oligonucléotide immunostimulateur possédant une terminaison accessible 5'.

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