A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 31/7105 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07H 21/02 (2006.01)
Patent
CA 2622679
Immunostimulatory single-stranded oligoribonucleotides (ssORN) with phosphodiester backbones induce TLR7-independent and MyD88-dependent immune activation. These immunostimulatory ssORN are useful to induce a ThI -like immune response in a subject, to induce an antigen-specific immune response in a subject, and to treat a subject having a cancer, an infectious disease, an allergic condition, or asthma.
L'invention concerne des oligoribonucléotides simple brin immunostimulateurs (ssORN) à squelettes phosphodiester induisant une activation immune indépendante de TLR7 et dépendant de MyD88. Ces ssORN immunostimulateurs sont utilisés pour induire un réponse immune de type ThI chez un sujet, pour induire une réponse immune spécifique à l'antigène chez un sujet, et pour traiter un sujet souffrant d'un cancer, d'une maladie infectieuse, d'un état allergique ou d'asthme.
Coley Pharmaceutical Gmbh
Sim & Mcburney
LandOfFree
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