Immunosuppressant agent

Details Immunosuppressant agent Immunosuppressant agent

C - Chemistry, Metallurgy

07

H

167/202, 260/228

C07H 15/04 (2006.01) A61K 31/70 (2006.01) C07H 19/01 (2006.01) C12P 17/18 (2006.01) C12P 19/26 (2006.01)

Patent

CA 1334392

Described is a process for producing a new immunosuppressant, "demethimmunomycin" (L-683,742) a C-31 demethylated analog of L-683,590 under novel fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosup- pressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

604437

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