Immunosuppressant-producing culture

Details Immunosuppressant-producing culture Immunosuppressant-producing culture

C - Chemistry, Metallurgy

12

N

195/34.7

C12N 1/20 (2006.01) C12P 17/18 (2006.01)

Patent

CA 1315227

TITLE OF THE INVENTION NEW IMMUNOSUPPRESSANT-PRODUCING CULTURE ABSTRACT OF THE DISCLOSURE Described is a new microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The microorganism acts as a demethylating agent and can produce the new immunosuppressants, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934, and "demethimmuno- mycin" (L-683,742) a C-31 demethylated analog of L-683,590, bnder novel fermentation conditions. These macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

607325

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