Immunosuppressive compounds

Details Immunosuppressive compounds Immunosuppressive compounds

C - Chemistry, Metallurgy

07

D

C07D 211/60 (2006.01) A61K 31/22 (2006.01) A61K 31/33 (2006.01) C07C 233/56 (2006.01) C07C 235/34 (2006.01) C07C 235/74 (2006.01) C07D 207/16 (2006.01) C07D 317/60 (2006.01) C07D 401/06 (2006.01) C07D 403/02 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2086428

2086428 9200278 PCTABS00010 This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit the prolyl peptidyl cis-trans isomerase (rotamase) activity of the FKBP and inhibit T cell activation. As such, the compounds of this invention can be used as immunosuppressive drugs to prevent or significantly reduce graft rejection in bone marrow and organ transplantations and for use in the treatment of a wide variety of autoimmune diseases in humans and other mammals.

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