Immunosuppressive compounds and methods

Details Immunosuppressive compounds and methods Immunosuppressive compounds and methods

C - Chemistry, Metallurgy

07

D

C07D 493/22 (2006.01) A61K 31/365 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) C07D 307/77 (2006.01)

Patent

CA 2248266

Compounds having the structure: (see formula I) and methods for use in immunosuppressive and anti-inflammatory treatment, and for inhibiting male fertility, are described. The compounds are triptolide analogs with improved water solubility and low toxicity.

Cette invention se rapporte à des composés et à des procédés conçus pour être utilisés dans des traitements immunosupressifs et anti-inflammatoires, et pour inhiber la fertilité masculine. Ces composés sont des analogues de triptolides présentant une meilleure solubilité dans l'eau et une faible toxicité.__________________

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