A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/365 (2006.01) C07D 209/60 (2006.01) C07D 261/20 (2006.01) C07D 307/92 (2006.01) C07D 491/04 (2006.01) C07D 493/04 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2162760
Immunosuppressive cyclolignan derivatives are provided of formula (I) or (II): Image (I) or Image (II) in which R1 is hydrogen, hydroxy, alkoxy; R2 and R3 are hydrogen, alkyl, acyl, or together R2 and R3 form a group -CHR4-; R4 is hydrogen, alkyl, alkenyl, hydroxyalkyl, (poly)haloalkyl, aryl, acyloxyalkyl, alkoxy, carboxyalkyl, alkoxycarbonyl, carbamoyl; R5 when present is hydrogen, alkyl, alkenyl, aryl, (poly)haloalkyl, acyl, carbamoyl, or thiocarbamoyl; R6 is alkyl, hydroxyalkyl, haloalkyl, acyl, acyloxyalkyl, carboxy or alkoxycarbonyl; Ar is 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5- dialkoxyphenyl; and X is nitrogen or oxygen.
Castro Maria Angeles
Del Corral Jose Maria Miguel
Faircloth Glynn T.
Gordaliza Marina
Lopez Maria Luisa
Marks & Clerk
Universidad de Salamanca
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