Immunosuppressive effects of pteridine derivatives

Details Immunosuppressive effects of pteridine derivatives Immunosuppressive effects of pteridine derivatives

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 45/06 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) C07D 475/00 (2006.01) C07D 475/04 (2006.01) C07D 475/08 (2006.01)

Patent

CA 2534151

This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro- derivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.

La présente invention concerne un groupe de dérivés de ptéridine trisubstitués et tétrasubstitués, leurs sels, N-oxydes, solvates, dérivés dihydro et tétrahydro et énantiomères acceptables d'un point de vue pharmaceutique, qui présentent de façon inattendue des propriétés pharmaceutiques souhaitables, notamment qui sont des agents immunosuppresseurs très actifs et qui sont par conséquent utilisés pour traiter un rejet de greffe et/ou pour traiter certaines maladies inflammatoires. Ces composés sont également utilisés pour prévenir ou traiter des troubles cardiovasculaires, des pathologies allergiques, des troubles du système nerveux central et des troubles de prolifération cellulaire.

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