Immunosuppressive effects of pteridine derivatives

Details Immunosuppressive effects of pteridine derivatives Immunosuppressive effects of pteridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 475/00 (2006.01) A61K 31/519 (2006.01) C07D 475/02 (2006.01)

Patent

CA 2526651

Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.

De nouvelles ptéridinediones (lumazines) polysubstituées ou des 2-thiolumazines, 4-thiolumazines ou 2,4-dithiolumazines polysubstituées, ayant des substituants décrits, en positions 1, 3, 6 et 7 du noyau ptéridine, ainsi que des sels pharmaceutiquement acceptables de ces composés, sont utilisés comme ingrédients biologiquement actifs dans la préparation de compositions pharmaceutiques, notamment pour le traitement ou la prévention d'un trouble CNS, d'un trouble de prolifération cellulaire, d'une infection virale, d'un trouble immun ou auto-immun ou d'un rejet de transplant. L'invention concerne en outre des combinaisons des dérivés de ptéridine selon l'invention avec un médicament immunosuppresseur ou immunomodulateur, un médicament antinéoplastique ou un agent antiviral, à effets synergiques potentiels.

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