Immunosupressing agent and process of producing the same

Details Immunosupressing agent and process of producing the same Immunosupressing agent and process of producing the same

A - Human Necessities

61

K

A61K 31/485 (2006.01) C07D 489/09 (2006.01) C07D 491/18 (2006.01) C07D 491/20 (2006.01)

Patent

CA 2045481

An immunosuppressive agent which has low toxicity and which exhibits excellent effectiveness even if it is orally administered is presented. The immunosuppressive agent of the present invention is characterized in that it contains .delta.-opioid antagonist having high selectivity to .delta.-opioid receptor. The present invention also provides a process of producing a naltrindole derivative characterized by reacting naltrexone or a salt thereof with a phenylhydrazine derivative in a solvent in the presence of methanesulfonic acid.

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